Fig. 2

The effect of AP and andrographolide on cognitive functions in alchor/D-gal induced AD mice. MWM test was conducted to assess the cognitive capacity of the mice after treatment with AP and andrographolide. (A) Typical swimming paths in the training trials on day 4; (B) Line chart of time needed to find the hidden platform (escape latency) from day 1 to day 4 during the training trials; (C) Quantitative analysis of escape latency of mice on day 4; (D)Average swimming speed in the probe trails; (E) Percent of time spent in the target quadrant; (F)Number of platform crossing. model group;(G) HE staining of the hippocampal CA1 region (original magnifcation, ×400, scale bars = 200 μm); (H) Number of neuronal cells in hippocampus CA1. Values are mean ± SD (n = 10). *P < 0.05, **P < 0.01, ***P < 0.001 vs. normal group, ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs. model group, ⁺P < 0.05 vs. donepezil group