Ammidin ameliorates myocardial hypoxia/reoxygenation injury by inhibiting the ACSL4/AMPK/mTOR-mediated ferroptosis pathway

Table 2 Binding abilities between drug components of Angelica dahurica and target proteins

Protein	PDBID	Ligand	Binding Affinity
AMPK	6C9H	Ammidin	−8.6
AMPK	6C9H	Mandenol	−5.7
AMPK	6C9H	Alloisoimperatorin	−8.5
mTOR	4DRI	Ammidin	−9.2
mTOR	4DRI	Mandenol	−6.7
mTOR	4DRI	Alloisoimperatorin	−8.9
ACSL4	AlphaFold2	Ammidin	−7.7
ACSL4	AlphaFold2	Mandenol	−5.7
ACSL4	AlphaFold2	Alloisoimperatorin	−8.2

Note: The absolute value of > 4.25 indicated certain binding activity, that of > 5.0 good binding activity and that of > 7.0 a strong binding activity

ISSN: 2662-7671