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Table 2 IC50 (μg/ml) values against COX-1 and COX-2 for n-hexane and defatted methanol extracts from A. Leucoclada and the COX-1/COX-2 selectivityy index

From: Phytochemical investigation and anti-inflammatory potential of Atriplex leucoclada Boiss

 

COX-1

COX-2

SI

Ibuprofen

6.88 ± 0.27

2.68 ± 0.1

2.56

ATH

16.74 ± 0.94***

5.96 ± 0.22***

2.81

ATD

41.22 ± 1.18***, ###

14.4 ± 0.54***, ###

2.86

  1. Defatted methanol extract (ATD); n-hexane extract (ATH); Cyclooxygenase (COX); The half of the inhibitory concentration (IC50). Selectivity index (SI) = IC50 COX-1/IC50 COX-2. Data in the Table expressed mean ± SEM (n = 3). Where ***P < 0.001 consider statistically significant compared to ibuprofen and ###P < 0.001 consider statistically significant compared to ATH group using one-way ANOVA followed by Tukey’s post hoc test
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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