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Table 3 The effect of SP extract on MDA, GSH contents and antioxidant enzyme activities in various tissues

From: Ameliorative effects of Scutellaria Pinnatifida subsp. pichleri (Stapf) Rech.f. Extract in streptozotocin-induced diabetic rats: chemical composition, biochemical and histopathological evaluation

Tissues

Parameters

Control

DM

DM + SP-100

DM + SP-200

DM + SP-400

DM + Gly-3

Liver

MDA (nmol/g prt)

0.61 ± 0.02

0.76 ± 0.02**

0.70 ± 0.04

0.60 ± 0.02##

0.63 ± 0.02#

0.62 ± 0.01##

GSH (GSH/mg prt)

92.56 ± 1.46

76.79 ± 3.06****

84.93 ± 1.82

80.65 ± 1.36

85.23 ± 2.10#

85.07 ± 1.22#

GST (nmol/g prt)

155.83 ± 2.17

144.14 ± 2.43

148 ± 6.44

138.79 ± 3.56

162.24 ± 5.32

149.61 ± 3.72

GR (U/g prt)

2.90 ± 0.06

2.61 ± 0.11

2.83 ± 0.07

2.83 ± 0.12

3.13 ± 0.10##

2.87 ± 0.05

CAT (nmol/g prt)

24.71 ± 1.13

20.93 ± 0.61*

22.42 ± 0.93

19.39 ± 0.98

20.65 ± 0.60

21.01 ± 0.60

SOD (pg/mg prt)

266.19 ± 19.95

223.40 ± 18.40

233.83 ± 11.82

295.97 ± 57.52

246.97 ± 19.03

226.47 ± 9.25

GPx (IU/mg prt)

34.24 ± 4.04

29.3 ± 0.46

36.02 ± 2.77

32.4 ± 3.90

38.13 ± 2.02

44.08 ± 3.74#

Kidney

MDA (nmol/g prt)

1.21 ± 0.06

1.63 ± 0.04****

1.32 ± 0.07###

1.39 ± 0.03#

1.27 ± 0.04###

1.27 ± 0.04####

GSH (GSH/mg prt)

119.81 ± 6.45

108.04 ± 3.53

115.47 ± 3.04

119.46 ± 1.32

119.48 ± 3.01

119.52 ± 3.67

GST (nmol/g prt)

19.01 ± 0.33

17.55 ± 0.88

18.16 ± 1.17

20.40 ± 1.12

20.15 ± 0.29

17.20 ± 0.93

GR (U/g prt)

6.38 ± 0. 18

5.73 ± 0.17

6.23 ± 0.26

6.11 ± 0.21

5.77 ± 0.19

6.07 ± 0.23

CAT (nmol/g prt)

12.86 ± 0.52

10.73 ± 0.51

10.79 ± 0.49

11.80 ± 0.39

11.25 ± 0.51

11.67 ± 0.51

SOD (pg/mg prt)

678.68 ± 60.81

429.74 ± 24.48**

455.23 ± 33.41

523.70 ± 33.56

473.36 ± 26.67

459.07 ± 45.30

GPx (IU/mg prt)

105.83 ± 15.09

61.66 ± 4.04**

63.02 ± 4.28

75.08 ± 5.84

68.20 ± 4.31

82.25 ± 7.20

Pancreas

MDA (nmol/g prt)

3.09 ± 0.14

4.45 ± 0.19**

4.30 ± 0.15

4.10 ± 0.31

3.21 ± 0.40#

3.40 ± 0.24

GSH (GSH/mg prt)

173.13 ± 11.26

89.98 ± 9.22****

105.50 ± 7.23

129.66 ± 12.46

149.49 ± 13.76##

131.23 ± 8.15

GST (nmol/g prt)

25.69 ± 2.13

15.61 ± 1.22*

13.43 ± 0.93

23.32 ± 2.92

28.32 ± 2.55##

21.25 ± 1.31

GR (U/g prt)

7.08 ± 0.42

5.33 ± 0.46

7.08 ± 0.50

5.18 ± 0.46

6.54 ± 0.29

5.94 ± 0.38

CAT (nmol/g prt)

4.27 ± 0.14

1.71 ± 0.12****

2.22 ± 0.13

3.82 ± 0.18####

3.84 ± 0.31####

3.66 ± 0.25####

SOD (pg/mg prt)

1509.41 ± 118.91

1485.23 ± 162.85

2184.34 ± 276.28

2501.17 ± 270.30#

1712.02 ± 187.39

2575.47 ± 263.70#

GPx (IU/mg prt)

185.71 ± 16.40

180.51 ± 8.49

239.86 ± 34.13

282.10 ± 26.28

230.63 ± 27.36

324.05 ± 37.99#

  1. Data are presented as mean ± standard error of mean (SEM). Control vs. DM: *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001; DM vs. all treatment groups: #P < 0.05, ##P < 0.01, ###P < 0.001 and ####P < 0.0001. MDA: Malondialdehyde; GSH: Reduced glutathione; GST: Glutathione-S-transferase; GR: Glutathione reductase; CAT: Catalase; SOD: Superoxide dismutase; GPx: Glutathione peroxidase; DM: Diabetes mellitus; SP: Scutellaria pinnatifida; Gly: Glibenclamide