Fig. 3

Microscopic image of the liver tissue. The liver tissue in the control (A) group was a normal histological architecture, the liver in the DM (B) group had severe degeneration (arrow) and moderate necrosis (arrowhead), DM + SP-100 (C) and DM + SP-200 (D) groups had mild degeneration (arrow), DM + Gly (F) and DM + SP-400 (E) groups had normal histological architecture. H&E. Data are presented as mean ± standard error of mean (SEM). Control vs. DM: ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 and ^****P < 0.0001; DM vs. all treatment groups: ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 and ^####P < 0.0001