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Table 3 Effect of gallic acid on oxidant/antioxidant parameters following uranyl acetate-induced liver dysfunction in rats

From: Gallic acid rescues uranyl acetate induced-hepatic dysfunction in rats by its antioxidant and cytoprotective potentials

Parameters/Groups

Control

UA

GA + UA

P value

Liver MDA level (nmol/mg protein)

3.649 ± 0.454

5.082 ± 0.558#

2.820 ± 0.413&

0.015

Liver NO level (nmol/mg protein)

96.138 ± 8.952

68.085 ± 6.149#

149.783 ± 11.535&Ω

0.000

Plasma TAC (nmol/ml)

0.236 ± 0.043

0.069 ± 0.007#

0.192 ± 0.032&

0.005

Liver SOD activity (nmol/mg protein)

20.483 ± 1.332

7.077 ± 1.691#

19.230 ± 1.878&

0.001

Liver GSH level (nmol/mg protein)

15.385 ± 0.614

13.010 ± 0.363#

15.412 ± 0.587&

0.004

Liver GSSG level (nmol/mg protein)

0.372 ± 0.010

0.595 ± 0.017#

0.446 ± 0.013&Ω

0.000

Liver GST level (µmol CDNB-GSH conjugate formed/min/mg protein)

62.969 ± 2.226

57.244 ± 2.023#

40.071 ± 1.416&

0.000

Liver GR activity (nmol of GSSG utilized/min/mg protein)

16.289 ± 0.842

8.144 ± 0.421#

13.031 ± 0.674&Ω

0.000

Liver GPx activity (nmol of GSH oxidized/min/mg protein)

254.577 ± 5.732

178.204 ± 4.012#

229.119 ± 5.158&Ω

0.000

  1. UA: uranyl acetate; GA: gallic acid; MDA: malondialdehyde; NO: nitric oxide; TAC: total antioxidant capacity; SOD: superoxide dismutase; GSH: reduced glutathione; GSSG: oxidized glutathione; GST: glutathione-S-transferase; CDNB: 1-chloro-2,4-dinitrobenzene; GR: glutathione reductase; GPx: glutathione peroxidase
  2. Results are expressed as the mean ± SEM of 6 rats per group (One-way ANOVA followed by Duncan post-test)
  3. # = significant difference between UA and the control groups
  4. & = significant difference between GA + UA and the UA groups
  5. Ω = significant difference between GA + UA and the control groups