Brazilian green propolis prevent Alzheimer’s disease-like cognitive impairment induced by amyloid beta in mice

Table 1 Genes suppressed by Brazilian green propolis treatment in the hippocampus

Gene Symbol	Gene Accession	Value (LOG₂ Ratio)			Log Ratio ¹⁾	p-value ¹⁾	Log Ratio ²⁾	p-value ²⁾
Gene Symbol	Gene Accession	Sham	Aβ	Aβ + PP900	Log Ratio ¹⁾	p-value ¹⁾	Log Ratio ²⁾	p-value ²⁾
Lcn2	NM_008491	3.8	8.0	6.2	4.13	< 0.001	−1.73	0.184
Trem2	NM_010821	7.5	10.4	9.8	2.93	0.002	−0.63	0.110
Spp1	NM_001204201	5.2	8.0	6.9	2.84	0.010	−1.15	0.457
Cxcl13	NM_011337	4.7	7.0	6.4	2.29	0.007	−0.57	0.131
Kcnj13	NM_001110227	14.0	10.1	11.08	−3.95	0.013	1.02	0.110
Folr1	NM_001252552	11.4	8.1	9.20	−3.29	0.040	1.09	0.184

¹⁾ Log ratio between the sham and Aβ groups, p-value determined using Student’s t-test
²⁾ Log ratio between the Aβ and Aβ + PP900 groups, p-value determined using Student’s t-test
Sham group [sham operation plus vehicle (0.5% methylcellulose) treatment]; Aβ group (ICV Aβ_25‒35 injection plus vehicle treatment); Aβ + PP900 group (ICV Aβ_25‒35 injection plus 900 mg/kg b.w. Brazilian green propolis)

ISSN: 2662-7671