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Table 7 Plasma protein binding (PPB) rate prediction of diosbulbin C and reference drugs

From: Diosbulbin C, a novel active ingredient in Dioscorea bulbifera L. extract, inhibits lung cancer cell proliferation by inducing G0/G1 phase cell cycle arrest

Compound

PPB

Prediction

Applicability #MD

Applicability #Mdpvalue

Diosbulbin C

-5.85853

FALSE

14.0422

8.61E-05

Cisplatin

-2.4272

FALSE

12.0232

0.0899

Carboplatin

-6.36358

FALSE

12.7016

0.0148

Gefitinib

2.80835

TRUE

18.2978

7.72E-17

Paclitaxel

19.7216

TRUE

15.1283

3.26E-07

Adriamycin

-44.2484

FALSE

12.3558

0.0397