Diosbulbin C, a novel active ingredient in Dioscorea bulbifera L. extract, inhibits lung cancer cell proliferation by inducing G0/G1 phase cell cycle arrest

Table 5 Cytochrome P450 2D6 inhibitor prediction of diosbulbin C and reference drugs

Compound	CYP2D6	Prediction	Applicability #MD	Applicability #Mdpvalue
Diosbulbin C	-8.41546	FALSE	13.0778	2.53E-04
Cisplatin	-3.65351	FALSE	24.1542	9.31E-17
Carboplatin	-4.16077	FALSE	16.8463	1.55E-08
Gefitinib	2.41414	TRUE	24.2807	6.84E-17
Paclitaxel	-9.84616	FALSE	12.6519	6.87E-04
Adriamycin	-8.00888	FALSE	18.2551	3.60E-10

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