Table 1 Top 25 representative pathways obtained from DAVID

Activation of Matrix Metalloproteinases

6

1.72E-07

MMP14, MMP13, MMP1, MMP2, MMP9, MMP10

Collagen degradation

7

1.75E-07

MMP12, MMP14, MMP13, MMP1, MMP2, MMP9, MMP10

Extra-nuclear estrogen signaling

7

5.32E-07

SRC, MMP2, MAPK1, AKT1, MMP9, EGFR, IGF1R

Degradation of the extracellular matrix

8

1.15E-06

MMP12, MMP14, MMP13, MMP1, CASP3, MMP2, MMP9, MMP10

PI3K/AKT Signaling in Cancer

7

3.14E-06

PDGFRB, SRC, MDM2, AKT1, MET, EGFR, FGFR1

PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

7

3.51E-06

PDGFRB, SRC, MAPK1, AKT1, MET, EGFR, FGFR1

Negative regulation of the PI3K/AKT network

7

5.10E-06

PDGFRB, SRC, MAPK1, AKT1, MET, EGFR, FGFR1

Diseases of signal transduction by growth factor receptors and second messengers

11

5.58E-06

PDGFRB, CREBBP, SRC, MDM2, KDR, MAPK1, CTNNB1, AKT1, MET, EGFR, FGFR1

Extracellular matrix organization

9

2.04E-05

MMP12, MMP14, MMP13, MMP1, CASP3, MMP2, KDR, MMP9, MMP10

ESR-mediated signaling

8

2.48E-05

CREBBP, SRC, MMP2, MAPK1, AKT1, MMP9, EGFR, IGF1R

Signaling by Receptor Tyrosine Kinases

11

2.81E-05

PDGFRB, SRC, KDR, MAPK1, CTNNB1, AKT1, MET, MMP9, EGFR, FGFR1, IGF1R

PIP3 activates AKT signaling

8

7.82E-05

PDGFRB, SRC, MDM2, MAPK1, AKT1, MET, EGFR, FGFR1

Disease

18

1.16E-04

CTSA, PDGFRB, CREBBP, PARP1, SRC, NR3C1, EGFR, MAPK8, IMPDH2, MDM2, CASP1, KDR, DNMT3B, AKT1, MAPK1, CTNNB1, MET, FGFR1

Signaling by Nuclear Receptors

8

1.59E-04

CREBBP, SRC, MMP2, MAPK1, AKT1, MMP9, EGFR, IGF1R

Intracellular signaling by second messengers

8

1.94E-04

PDGFRB, SRC, MDM2, MAPK1, AKT1, MET, EGFR, FGFR1

Constitutive Signaling by Aberrant PI3K in Cancer

5

2.51E-04

PDGFRB, SRC, MET, EGFR, FGFR1

Signaling by Interleukins

9

4.07E-04

MAPK8, MMP1, ALOX5, CASP3, MMP2, CASP1, MAPK1, AKT1, MMP9

Interleukin-4 and Interleukin-13 signaling

5

8.65E-04

MMP1, ALOX5, MMP2, AKT1, MMP9

Transcriptional regulation by RUNX2

5

1.32E-03

MMP13, SRC, MAPK1, AKT1, NR3C1

Intrinsic Pathway for Apoptosis

4

1.34E-03

MAPK8, CASP3, MAPK1, AKT1

Programmed Cell Death

6

1.40E-03

MAPK8, CASP3, CASP1, MAPK1, CTNNB1, AKT1

Innate Immune System

12

2.33E-03

CTSA, ACLY, CREBBP, MAPK8, SRC, ALOX5, GSTP1, IMPDH2, CASP1, MAPK1, CTNNB1, MMP9

Generic Transcription Pathway

13

2.52E-03

CREBBP, PARP1, SRC, GSR, NR3C1, EGFR, MMP13, MDM2, CASP1, AKT1, MAPK1, CTNNB1, MET

Mitotic G1 phase and G1/S transition

5

2.76E-03

DHFR, WEE1, SRC, AKT1, TYMS

Listeria monocytogenes entry into host cells

3

2.82E-03

SRC, CTNNB1, MET