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Fig. 6 | BMC Complementary Medicine and Therapies

Fig. 6

From: Diosbulbin C, a novel active ingredient in Dioscorea bulbifera L. extract, inhibits lung cancer cell proliferation by inducing G0/G1 phase cell cycle arrest

Fig. 6

Molecular docking and ADMET of diosbulbin C. A Diosbulbin C exhibits high binding affinity to AKT1 protein via sites of Val164, Asp292, Glu234, Met281, Lys158, Gly159, Gly162, Thr160 and Phe161 through molecular docking analysis. B Diosbulbin C exhibits high binding affinity to DHFR protein via sites of Gly117, Gly116, Val115, Phe34, Ile60 and Pro61 through molecular docking analysis. C Diosbulbin C exhibits high binding affinity to TYMS protein via sites of Tyr258, Asp49, His256, Asp254, Ser216, Pro12, His196, Arg185 and Lys107 through molecular docking analysis. D ADMET Plot is plotted by ADMET_PSA_2D vs ADMET_AlogP98. The dark blue dots represent the AlogP98 of diosbulbin C. The red and green ellipses represent 95% and 99% confidence intervals of the human intestinal absorption model, respectively, and the rose red and light blue ellipses represent 95% and 99% confidence intervals of the blood–brain barrier permeability (BBB) model, respectively

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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