Fig. 9

Validation of Apigenin treatment on human breast cancer cells using GEO datasets. A, D Scatter plots illustrating the significant KEGG pathways enriched by the up- and down-regulated differentially expressed genes (DEGs) within indicated GEO datasets. The y-axis represents the name of pathway, and the x-axis represents the up- and down-regulated DEGs. Dot size represents the combined score, and the colour indicates the log₁₀(\(\frac{1}{Pvalue}\)). (B, C, E, F) Heatmaps showing transcriptional levels of genes enriched in each representative pathway of Apigenin-treated breast cancer cells compared to vehicle