Melittin as a safe compound to BALB/c mice immune system; a tiered approach immunotoxicity screening

Table 1 The subacute effects of i.p administration of melittin on hematological parameters in different groups of mice

Parameters	Normal Saline	Melittin 0.75 mg/kg	Melittin 1.5 mg/kg	CYP 20 mg/kg
White Blood Cells	6783 ± 289	6417 ± 244	5460 ± 554	3900 ± 445^***
Neutrophil	2137 ± 82	1858 ± 251	1450 ± 397	1505 ± 229^*
Lymphocyte	4498 ± 301	4395 ± 83	3726 ± 405	2273 ± 259^***
Monocyte	105 ± 19	100 ± 27	97 ± 31	79 ± 28
Eosinophil	43 ± 14	64 ± 2	32 ± 16	43 ± 17
Spleen cellularity	162 ± 39	123 ± 12	130 ± 26	93 ± 16^*

Data are shown as mean ± SEM. ^*P < 0.05, ^***P < 0.001 indicate significant changes compared to the negative control group

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