Table 1 The composition of designed formulations, water- and oil-based gel
Formulation | Gel Base | Solvent | Sodium carboxymethyl cellulose (% w/v) | Carbomer (% w/v) | PEG400 (% w/v) | PEG4000 (% w/v) |
|---|---|---|---|---|---|---|
F1 | W | Sodium chloride 0.9% w/v | 2 | 1 | - | - |
F2 | W | Ringer's solution | 2 | 1 | - | - |
F3 | W | HEPES buffer1M (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) | 2 | 1 | - | - |
F4 | O | Glycerol 46.15% w/v | - | - | 46.15 | 7.7 |
F5 | O | Olive oil 46.15% w/v | - | - | 46.15 | 7.7 |