Table 1 PICO criteria

Patient

Cancer patients (all entities and stages)

Adult patients (aged > 18)

All sexes, all ethnicities

Patients with precancerous conditions or Carcinoma in situ

Preclinical studies

Primary Prevention

Study populations with more than 20% children or precancerous conditions

Intervention

Every intervention with reflexology

Comparison

All possible control groups (active, placebo, standard care, observation)

Other study types (one-armed/non-controlled studies, case reports or series)

Outcome

Mortality

Morbidity

Patient reported outcomes (with validated measurement tools)

Symptoms measured with validated instruments

Adverse effects

Laboratory parameters without diagnosis (except established surrogates for patient relevant outcomes; for example cortisol for stress)

Others

Meta-analyses, systemic reviews and RCTs

Language: German and English

Full publication

Grey literature (conference articles, abstracts, letters, ongoing studies, unpublished literature,…)