Combinative effects of akarkara root-derived metabolites on anti-inflammatory and anti-alzheimer key enzymes: integrating bioassay-guided fractionation, GC-MS analysis, and in silico studies

Table 5 The central nervous system (CNS) distribution values of the isolated compounds calculated using pkCSM web server

Compound	Distribution
Compound	BBB permeability (log BB)^a	CNS permeability (log PS)^b
Oleamide (A1)	-0.397	-1.651
Stigmasterol (A2)	0.811	-1.033
Deca-2E,4E-dienoic acid 2-phenylethylamide (A3)	0.603	-0.976
Pellitorine (A4)	0.633	1.596
Donepezil	0.157	-1.464

^alog BB should be > 0.3 and not less than − 1 for a compound to readily across the BBB
^blog PS should be > -2 and not less than − 3 for a compound to penetrate the CNS

ISSN: 2662-7671