Fig. 4

(A) In vitro COX-2 and 5-LOX, as well as in LPS-induced RAW264.7 macrophages (iNOs) anti-inflammatory activities, and (B) the inhibitory effect of pro-inflammatory cytokines (TNF- α, IL-1β, and IL-6) secretion in LPS-stimulated RAW264.7 macrophage cells of the isolated compounds (A1-A4). Different letters on the bar indicate significant differences at P < 0.0001. * Significant from negative control at P < 0.0001. ^# Significant from positive control at P < 0.0001 with Tukey’s test