Fig. 1

Schematic experimental approaches. A Cells were treated, for 2 or 6 h, with Uncaria tomentosa (Ut) aqueous extract; after these periods, cultures were washed with PBS and incubated with PA solution in different concentrations, for 24 h (preventive condition); B Cells were incubated with PA in different concentrations, for 24 h; after, cultures were washed with PBS and, then, Ut aqueous extract was added, for 2 or 6 h (therapeutic condition) and analyzed after these periods