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Table 6 Prediction of acute oral toxicity and toxicity class of ligands

From: The anticancer potential of chemical constituents of Moringa oleifera targeting CDK-2 inhibition in estrogen receptor positive breast cancer using in-silico and in vitro approches

Ligands

LD50 predicted in

Rodent (mg/kg)

Toxicity Class

Chlorogenic acid

5000

V

Quercetin

159

III

Ellagic acid

2991

IV

Niazirin

3750

V

Kaempferol

3919

V

  1. Class I: fatal if swallowed (LD50 ≤ 5), Class II: fatal if swallowed (5 < LD50 ≤ 50). Class III: toxic if swallowed (50 < LD50 ≤ 300). Class IV: harmful if swallowed (300 < LD50 ≤ 2000). Class V: may be harmful if swallowed (2000 < LD50 ≤ 5000). Class VI: non-toxic (LD50 > 5000)