Fig. 7

GXNT ameliorated cerebral vascular imaging in T2DM ZDF rats with DE. Cerebral vascular status in experimental rats was observed and assessed by MRA. Two rats from each group were randomly selected for MRA scans. (a) illustrates the intracerebral vascular status in normal rats: the vertebral artery was strong, and the intracerebral artery was clearly visible, without stenosis or occlusion. (b) illustrates the intracerebral vascular status in model rats: the vertebral artery was strong, but the intracerebral artery showed segmental stenosis, fewer distal branches and poor development, severe occlusion such as interrupted blood flow, and no distal development. (c) illustrates the intracerebral vascular status in rats treated with GXNT 300 mg/kg: the vertebral artery was strong, with partial cerebral artery occlusion and branch artery stenosis. (d) illustrates the intracerebral vascular status in rats treated with GXNT 600 mg/kg: the vertebral artery was strong; no occlusion of the internal cerebral artery; mild stenosis of the branch artery. (e) illustrates the intracerebral vascular status in rats treated with Met 300 mg/kg: the vertebral artery was strong, but the intracerebral artery showed segmental stenosis, fewer distal branches, and poor development. The vertebral artery is marked by red arrows; the intracerebral artery is marked by yellow arrows; and the branch artery is marked by green arrows