Fig. 10

Effect of GXNT on microvascular immunofluorescence of brain tissue in T2DM ZDF rats with DE. The localization of ALB and IgG was assessed by immunofluorescence. Green fluorescence indicates ALB-stained and IgG-stained endothelial cells, and blue indicates DAPI- stained nuclei. Scale bar: 100 μm. (a) Representative immunofluorescence images show the expression of IgG in the indicated rats. (b) Representative immunofluorescence images show the expression of ALB in the indicated rats. (c) Quantitative analysis of the IgG area in each group. (d) Quantitative analysis of the ALB area in each group. GXNT, Guanxinning tablet; Met, metformin. Data are expressed as mean ± SEM, n = 8. * p < 0.05, ** P < 0.01 vs. normal group (Zucker lean control rats); #P < 0.05, ##P < 0.01 vs. model group