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Table 1 Assessment of anticoagulant activity by APTT and PT.

From: Some new insights into the biological activities of carboxymethylated polysaccharides from Lasiodiplodia theobromae

Sample

Concentration

(µg/mL)

APTT (s)

PT (s)

Negative Control*

 

38.59 ± 0.60 a

15.04 ± 0.49 a

Heparin

10

34.31 ± 3.38 a

14.05 ± 1.30 a

25

130.36 ± 4.85 bc

20.69 ± 0.77 bc

50

> 300 bcd

24.76 ± 0.98 bcd

100

> 300 bcde

29.68 ± 0.94 bcde

LaEPS-C

5

36.87 ± 2.79 a

14.90 ± 0.64 a

10

36.24 ± 0.74 a

14.65 ± 0.90 a

25

35.59 ± 1.50 a

12.95 ± 0.17 a

50

31.29 ± 0.23 a

11.73 ± 0.24 b

100

31.75 ± 0.86 a

10.73 ± 0.63 b

BLaEPS-C

5

38.91 ± 0.45 a

15,73 ± 0,26 a

10

41.13 ± 1,38 a

14.98 ± 0,85 a

25

32.29 ± 4,98 a

14.56 ± 1,14 a

50

32.32 ± 0,65 a

12,28 ± 1,07 b

100

33.55 ± 4.02 a

13.38 ± 1.86 a

LLaEPS-C

5

44.21 ± 1.92 a

12.63 ± 0.28 b

10

37.56 ± 1.35 a

11.85 ± 0.87 b

25

34.69 ± 1.61 a

14.26 ± 0.10 b

50

35.31 ± 1.82 a

12.51 ± 0.66 a

100

32.76 ± 0.34 a

13.43 ± 1.24 a

  1. *Blood plasma with saline only (no LaEPS or heparin added)** Clotting time values ​​followed by the same letters do not differ statistically from each other (p > 0.05). The reference values for normality are 30–45 s and 10–14 s for the APTT and PT, respectively