The standardized extract of Centella asiatica L. Urb attenuates the convulsant effect induced by lithium/pilocarpine without affecting biochemical and haematological parameters in rats

Table 2 Liver function tests of rats treated with the vehicle, Centella asiatica or carbamazepine

Analyte	Vehicle (Purified Water)	Centella asiatica (200 mg/Kg)	Centella asiatica (400 mg/Kg)	Carbamazepine (300 mg/Kg)	Reference intervals*
Albumin	4.40 ± 0.14	4.44 ± 0.08	4.52 ± 0.08	4.45 ± 0.10	4.00–5.00 g/dL
ALT	50.24 ± 0.67	44.29 ± 2.93	48.29 ± 1.72	47.43 ± 3.24	19.00–53.00 UI/L
AST	153.5 ± 3.22	128.7 ± 8.77	152.4 ± 0.92	106.75 ± 8.29	63.00-157.00 UI/L
Direct bilirubin	0.03 ± 0.02	0.03 ± 0.01	0.03 ± 0.01	0.03 ± 0.02	0.03–0.06 mg/dL
Indirect bilirubin	0.00 ± 0.01	0.00 ± 0.02	0.01 ± 0.01	0.04 ± 0.02	0-0.10 mg/dL
Total bilirubin	0.18 ± 0.10	0.18 ± 0.02	0.18 ± 0.00	0.18 ± 0.00	0.04–0.20 mg/dL
Alkaline phosphatase	219.2 ± 31.01	146.6 ± 13.92	205.9 ± 25.79	264.4 ± 14.84	36.00-312.00UI/L
γ-Glutamyl transferase	17.26 ± 1.81	18.00 ± 1.63	21.14 ± 0.76	21.71 ± 0.94	8.8–24 UI/L
Total Protein	6.20 ± 0.14	6.24 ± 0.12	6.52 ± 0.11	6.28 ± 0.12	5.60–7.60 g/dL

Values are expressed as the mean ± SEM.*Source: Suckow et al., 2006 [47]; Giknis y Clifford, 2008 [48]; Sharp y Villano, 2013 [42]. Rivadeneyra et al., 2018 [49]

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