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Table 5 Effect of BTL on the liver and cardiovascular markers of animals

From: Cytotoxicity, acute and sub-chronic toxicities of the leaves of Bauhinia thonningii (Schumach.) Milne-Redh. (Caesalpiniaceae)

Sexes

Studies animals, doses, and values of investigated parameters

 

Parameters

Doses of BTL and values of parameters

  

Control (0 mg/kg)

250 mg/kg

500 mg/kg

1000 mg/kg

Females

Proteins (g/dL)

5.12 ± 0.30a

4.87 ± 0.16a

4.79 ± 0.41a

4.97 ± 0.54a

ALT (U/I)

40.46 ± 1.36b

33.46 ± 2.02a

36.36 ± 1.14a

46.37 ± 5.44b

AST (U/I)

80.90 ± 1.43a

75.36 ± 2.60a

74.63 ± 1.60a

83.93 ± 5.80b

TAG (mg/dL)

41.66 ± 2.9ab

47.96 ± 3.33b

35.55 ± 4.60a

45.92 ± 3.60b

Cholesterol(mg/dL)

84.00 ± 7.38a

80.75 ± 3.27a

72.75 ± 6.76a

85.62 ± 6.35a

LDL (mg/dL)

7.04 ± 0.87a

6.65 ± 0.39a

7.73 ± 0.22b

8.31 ± 0.20c

HDL (mg/dL)

68.62 ± 6.61ab

64.50 ± 3.63ab

57.90 ± 7.02a

68.13 ± 2.52b

Males

Proteins (g/dL)

6.53 ± 0.51a

6.27 ± 0.36a

6.23 ± 0.44a

6.77 ± 0.34a

ALT (U/I)

45.50 ± 1.06b

39.37 ± 0.57a

38.71 ± 1.95a

49.87 ± 5.10b

AST (U/I)

130.37 ± 7.30b

78.53 ± 8.57a

80.28 ± 7.07a

134.74 ± 7.26b

TG (mg/dL)

66.48 ± 5.32b

58.70 ± 8.79ab

50.00 ± 8.25a

71.85 ± 8.99b

Cholesterol (mg/dL)

86.58 ± 1.70a

79.50 ± 5.91a

95.50 ± 4.73b

97.37 ± 2.49b

LDL (mg/dL)

19.45 ± 0.81b

15.41 ± 0.42a

18.13 ± 1.16b

20.75 ± 0.91b

HDL (mg/dL)

53.75 ± 1.84a

52.35 ± 3.59a

66.63 ± 5.51b

62.25 ± 2.39b

  1. Data are expressed as mean ± SD, n = 4. Values for a given group in a Line followed by a different letter as a superscript were significantly different (p < 0.05). ALT alanine transaminase, AST aspartate transaminase, HDL high-density lipoprotein, LDL low-density lipoprotein, TG triglycerides