Skip to main content

Table 2 Cytotoxicity of the phytoconstituents isolated from the leaves of Bauhinia thonningii against the studied cancer cells

From: Cytotoxicity, acute and sub-chronic toxicities of the leaves of Bauhinia thonningii (Schumach.) Milne-Redh. (Caesalpiniaceae)

Cell lines

Samples, IC50 (µM), degrees of resistancea or selectivity indexb (in bracket)

1

2

3

4

5

6

7

8

9

10

CCRF-CEM

14.23 ± 0.94

12.02 ± 1.25

17.85 ± 1.67

27.32 ± 3.12

8.73 ± 0.62

9.12 ± 0.59

6.61 ± 0.41

3.03 ± 0.37

 > 50

44.28 ± 3.91

CEM/ADR5000

Degree of resistancea

10.28 ± 0.44

(0.72)

9.11 ± 0.18

(0.76)

10.24 ± 0.30

(0.57)

 > 50

(> 1.83)

7.21 ± 0.61

0.83)

7.88 ± 0.58

(0.90)

2.86 ± 0.17

(0.43)

2.42 ± 0.30

(0.80)

 > 50

 > 50

(> 1.13)

MDA-MB-231-pcDNA

11.28 ± 1.04

9.84 ± 0.66

11.02 ± 0.58

42.28 ± 3.29

7.24 ± 0.47

6.99 ± 0.28

1.93 ± 0.19

2.34 ± 0.31

 > 50

 > 50

MDA-MB-231-BCRP

Degree of resistance

16.98 ± 2.05

(1.51)

14.29 ± 1.12

(1.45)

13.19 ± 1.48

(1.20)

 > 50

(> 1.18)

16.82 ± 1.26

(2.32)

12.30 ± 0.97

(1.76)

8.15 ± 0.73

(4.22)

8.26 ± 0.66

(3.53)

 > 50

 > 50

HCT116 p53+/+

21.18 ± 2.45

12.27 ± 1.24

19.78 ± 0.78

 > 50

17.93 ± 1.26

21.84 ± 2.11

19.50 ± 2.05

9.59 ± 0.84

 > 50

 > 50

HCT116 p53−/−

Degree of resistance

10.77 ± 1.11

(0.51)

9.20 ± 0.45

(0.75)

17.23 ± 0.83

(0.87)

 > 50

13.20 ± 1.14

(0.73)

12.49 ± 1.36

(0.57)

9.71 ± 0.76

(0.50)

3.41 ± 0.35

(0.36)

 > 50

 > 50

U87MG

27.15 ± 3.07

24.78 ± 2.22

31.02 ± 2.65

 > 50

23.65 ± 1.77

19.03 ± 2.01

19.27 ± 1.62

8.01 ± 0.84

 > 50

 > 50

U87MG.ΔEGFR

Degree of resistance

26.63 ± 1.13

(0.98)

21.09 ± 2.40

(0.85)

19.75 ± 0.96

(0.64)

 > 50

31.09 ± 1.85

(1.31)

33.54 ± 2.79

(1.75)

18.01 ± 2.21

(0.93)

15.38 ± 0.64

(1.92)

 > 50

 > 50

HepG2

23.46 ± 0.59

19.55 ± 1.44

23.57 ± 3.23

 > 50

28.29 ± 1.74

21.48 ± 2.25

30.67 ± 1.86

19.39 ± 2.07

 > 50

 > 50

AML12

Selectivity indexb

 > 50

(> 2.13)

 > 50

(> 2.56)

 > 50

(> 212)

 > 50

 > 50

(> 1.77)

 > 50

(> 2.33)

 > 50

(> 1.63)

 > 50

(> 2.58)

 > 50

 > 50

  1. In bold: significant cytotoxic effect [61, 63]; Compounds: 6-C-methylquercetin-3, 4'-dimethyl ether (1); 6-C-methylquercetin-3,7-dimethyl ether (2); 6-C-methylquercetin 3,7,3'-trimethyl ether (3); quercetin (4); quercetin-3-O-L-rhamnopyranoside (5); quercetin-3-O-β-glucopyranoside (6); 6,8-C-dimethylkaempferol 3,7-dimethyl ether (7); 6,8-C-dimethylkaempferol-3-methyl ether (8) ursolic acid (9) and 3-O-β-D-glucopyranoside of β-sitosterol (10); a The degree of resistance was determined as the ratio of the IC50 in the resistant divided by the IC50 in the sensitive cell lines; CEM/ADR5000 versus CCRF-CEM, MDA-MB-231-BCRP versus MDA-MB-231-pcDNA, HCT116 p53−/− versus HCT116 p53+/+ and U87.MGΔEGFR versus U87.MG; b The selectivity index: ratio of IC50 in AML12 versus IC50 in HepG2 cells [36, 37]
Back to article page

BMC Complementary Medicine and Therapies

ISSN: 2662-7671

Contact us