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Table 5 Within- and between-group comparison of the changes in chemotherapy-induces complications during and after intervention

From: The effects of synbiotics supplementation on reducing chemotherapy-induced side effects in women with breast cancer: a randomized placebo-controlled double-blind clinical trial

Complications

Synbiotics (n = 34)

Placebo (n = 33)

std. Error

B

6Adjusted P value

5Unadjusted P value

Baseline

Week 4

Week 8

1P value 1,2

2P value 1,3

Baseline

Week 4

Week 8

3P value1,2 1,2

4P value1,3

Nausea/vomiting

20.35 ± 9.07

18.35 ± 8.39

17.17 ± 8.80

0.266

0.015

20.69 ± 5.22

21.57 ± 4.41

22.06 ± 4.54

0.450

0.386

1.867

1.591

0.394

0.085

Fatigue

40.29 ± 4.29

33.85 ± 4.82

30.55 ± 4.95

< 0.001

< 0.001

39.09 ± 4.54

39.72 ± 4.97

40.69 ± 5.09

0.195

0.032

1.373

5.069

< 0.001

< 0.001

Pain

4.17 ± 8.76

3.91 ± 7.17

3.82 ± 6.99

0.217

0.163

2.75 ± 4.18

2.84 ± 4.12

2.72 ± 3.94

0.734

0.887

1.252

− 0.710

0.570

0.414

Anorexia

20.61 ± 5.45

26.11 ± 7.02

28.64 ± 9.74

< 0.001

< 0.001

22.58 ± 5.88

22.60 ± 5.64

22.66 ± 5.88

0.910

0.624

1.731

− 0.934

0.590

0.097

Anorexia (VAS)

4.79 ± 1.43

5.85 ± 0.98

6.47 ± 1.61

< 0.001

< 0.001

4.96 ± 1.51

5.03 ± 1.48

4.87 ± 1.55

0.070

0.067

0.331

− 0.138

0.678

0.015

Sleep quality

12.88 ± 5.15

12.55 ± 4.78

12.35 ± 4.99

0.902

0.824

12.66 ± 4.45

12.57 ± 4.17

12.87 ± 4.37

0.790

0.901

1.234

− 0.049

0.968

0.921

Mental status

16.20 ± 8.21

15.02 ± 8.38

14.85 ± 8.29

0.156

0.533

16.06 ± 8.30

16.36 ± 8.52

16.24 ± 8.49

0.374

0.222

2.257

− 2.026

0.370

0.668

Weight (kg)

64.16 ± 6.56

64.47 ± 6.23

64.62 ± 6.09

0.825

0.574

65.69 ± 7.75

65.52 ± 8.09

65.19 ± 8.43

0.283

0.148

1.851

1.553

0.402

0.545

BMI (kg.m2)

24.62 ± 2.45

24.76 ± 2.37

24.82 ± 2.24

0.559

0.299

25.25 ± 2.48

25.19 ± 2.62

25.12 ± 2.63

0.168

0.218

0.523

0.577

0.271

0.443

Waist circumference (cm)

86.79 ± 9.60

86.97 ± 9.42

87.26 ± 9.17

0.901

0.631

87.15 ± 10.62

86.90 ± 10.86

86.84 ± 10.88

0.643

0.537

2.384

1.144

0.631

0.987

  1. data reported as mean ± SD
  2. 1within-group comparison between first and second visits in the synbiotics group conducted via GEE analysis (adjusted for energy, protein, calcium, and vitamin C intake)
  3. 2within-group comparison between second and third visits in the synbiotics group conducted via GEE analysis (adjusted for energy, protein, calcium, and vitamin C intake)
  4. 3 within-group comparison between first and second visits in the placebo group conducted via GEE analysis (adjusted for energy, fat, calcium, and fiber intake)
  5. 4within-group comparison between second and third visits in the placebo group conducted via GEE analysis (adjusted for energy, fat, calcium, and fiber intake)
  6. 5between-groups comparison conducted via GEE analysis
  7. 6between-groups comparison conducted via GEE analysis (adjusted for protein, fat, fiber, calcium, and vitamin C intake)
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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