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Table 2 Effects of selected crude extract from Prabchompoothaweep remedy on parasite level (day 6 and day 12 post-infection) and parasite suppression in experimental cerebral malaria (ECM) mice model at day 12 post-infection

From: Efficacy of artesunate combined with Atractylodes lancea or Prabchompoothaweep remedy extracts as adjunctive therapy for the treatment of cerebral malaria

Group

Dose

(mg/kg)

% Parasitemia

% Suppression

(Day 12)

Day 6

Day 12

P. berghei (PbA)

-

17.18 ± 1.49

35.80 ± 1.13 b, c, d, e, f

-

PbA + Artesunate (Art)

6

18.17 ± 1.01

15.14 ± 0.51 a, d, e, f

57.70 ± 1.43 d, e, f

PbA + A. lancea (AL)

400

16.02 ± 1.54

16.32 ± 0.94 a, d, e, f

54.41 ± 2.63 d, e, f

PbA + Prabchompoothaweep (PT)

600

17.28 ± 1.48

20.35 ± 0.61a, b, c, e, f

43.13 ± 1.72 b, c, e, f

PbA + Art + AL

Art 6 + AL 400

16.08 ± 1.22

7.78 ± 1.13 a, b, c, d

78.27 ± 3.15 b, c, d

PbA + Art + PT

Art 6 + PT 600

17.16 ± 0.49

6.34 ± 0.85 a, b, c, d

82.27 ± 2.38 b, c, d

  1. Results are shown as mean ± standard error of the mean (SEM) (n = 5 per group), p < 0.05. a compared to PbA-infected mice, b compared to artesunate, c compared to 400 mg/kg of A. lancea, d compared to 600 mg/kg of Prabchompoothaweep remedy, e compared to artesunate and A. lancea combination, and f compared to artesunate and Prabchompoothaweep remedy combination