Fig. 5

Selected crude extracts from Prabchompoothaweep remedy reduce pathohistological changes in the brain tissue in experimental cerebral malaria (ECM). C57BL/6 were inoculated with PbA erythrocytes and treated with selected crude extracts from Prabchompoothaweep remedy for 7 consecutive days. Brain histological sections of the control (A, B, C), infected untreated (D, E, F), artesunate treatment (G, H, I), A. lancea treatment (J, K, L), Prabchompoothaweep remedy treatment (M, N, O), Art-AL combination (P, Q, R), and Art-PT combination groups (S, T, U) stained with H&E solution. The control group shows the normal histological aspect in the cerebral cortex, containing healthy neurons and normal vessels (A), no leukocyte infiltration (B), and no brain hemorrhage (C). Arrowhead indicates a large number of infected red blood cells within the brain microvasculature of the infected group (D), while a small number of infected red blood cells are observed in the Prabchompoothaweep remedy group (M). The black arrow shows a large area of leukocyte infiltration in the infected group (E), whereas a small area of infiltration is observed in Art (H), A. lancea (K), and Prabchompoothaweep remedy (N). Yellow arrow demonstrates an extensive hemorrhagic area in the infected group (F), while a small hemorrhagic area is detected in the brain of mice treated with Art (I), A. lancea (L), Prabchompoothaweep remedy (O), Art-AL combination (R), and Art-PT combination group (U). Art, artesunate; AL, A. lancea; PT, Prabchompoothaweep remedy. The magnifications are 4X for panels B, E, H, K, N, Q, and T, 20X for panels C, F, I, L, O, R, U, and 100X for panels A, D, G, J, M, P, S