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Table 3 Fractional inhibitory concentration (FIC) and FIC indices (FICI) of antibiotic-extracts/ phases pairs, against A. baumannii

From: Medicinal plant Miconia albicans synergizes with ampicillin and ciprofloxacin against multi-drug resistant Acinetobacter baumannii and Staphylococcus aureus

Acinetobacter baumanniia

Ampicillin

Ciprofloxacin

Sample/Combination

Combined MIC

(µg/mL)

FIC

FICI

Result

Sample/Combination

Combined MIC

(µg/mL)

FIC

FICI

Result

SEE + AMP

  

2

Indifference

SEE + CIP

  

0.625

Additivity

SEE

1000

2

  

SEE

250

0.5

  

AMP

3.125

0.0016

  

CIP

12.5

0.125

  

SHxP + AMP

  

0.51

Additivity

SHxP + CIP

  

0.27

Synergism

SHxP

500

0.5

  

SHxP

250

0.25

  

AMP

12.5

0.0063

  

CIP

1.56

0.016

  

SEP + AMP

  

0.51

Additivity

SEP + CIP

  

0.25

Synergism

SEP

250

0.5

  

SEP

125

0.25

  

AMP

12.5

0.0063

  

CIP

0.195

0.002

  

SCP + AMP

  

0.5

Synergism

SCP + CIP

  

0.25

Synergism

SCP

500

0.5

  

SCP

125

0.125

  

AMP

1.56

7.8 × 10–4

  

CIP

12.5

0.125

  

SHP + AMP

  

0.5

Synergism

SHP + CIP

  

0.5

Synergism

SHP

500

0.5

  

SHP

500

0.5

  

AMP

0.049

2.5 × 10–5

  

CIP

0.05

5 × 10–4

  

LEE + AMP

  

0.51

Additivity

LEE + CIP

  

0.25

Synergism

LEE

500

0.5

  

LEE

125

0.125

  

AMP

25

0.0125

  

CIP

12.5

0.125

  

LHxP + AMP

  

0.28

Synergism

LHxP + CIP

  

0.13

Synergism

LHxP

500

0.25

  

LHxP

250

0.125

  

AMP

50

0.025

  

CIP

0.39

0.004

  

LEP + AMP

  

0.55

Additivity

LEP + CIP

  

0.31

Synergism

LEP

250

0.5

  

LEP

31.3

0.06

  

AMP

100

0.05

  

CIP

25

0.25

  

LCP + AMP

  

0.28

Synergism

LCP + CIP

  

0.25

Synergism

LCP

250

0.25

  

LCP

250

0.25

  

AMP

50

0.025

  

CIP

0.39

0.004

  

LHP + AMP

  

0.503

Additivity

LHP + CIP

  

0.38

Synergism

LHP

500

0.5

  

LHP

250

0.25

  

AMP

6.25

0.003

  

CIP

12.5

0.125

  

3 + AMP

  

2

Indifference

3 + CIP

  

2

Indifference

3

62.5

1

  

3

62.5

1

  

AMP

 > 2000

1

  

CIP

100

1

  

10 + AMP

  

2

Indifference

10 + CIP

  

2

Indifference

10

 ≥ 250

1

  

10

 ≥ 250

1

  

AMP

 > 2000

1

  

CIP

100

1

  

18 + AMP

  

2

Indifference

18 + CIP

  

2

Indifference

18

 ≥ 250

1

  

18

 ≥ 250

1

  

AMP

 > 2000

1

  

CIP

100

1

  
  1. aClinical strain, resistant to aminoglycosides, quinolones, 3rd and 4th generation cephalosporins, penicillins, carbapenems, piperacillin-tazobactam and trimethoprim – sulfamethoxazole. LEP leaves-ethyl acetate phase, LCP leaves-chloroform phase, LHP leaves-hydromethanolic phase, SEE stems-ethanol extract, SHxP stems-hexane phase, SEP stems-ethyl acetate phase, SCP stems-chloroform phase, SHP stems-hydromethanolic phase, AMP Ampicillin, CIP Ciprofloxacin. For FIC calculation, MIC values of LHxP and SHxP were considered = 2000 µg/mL
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