Medicinal plant Miconia albicans synergizes with ampicillin and ciprofloxacin against multi-drug resistant Acinetobacter baumannii and Staphylococcus aureus

Table 2 Fractional inhibitory concentration (FIC) and FIC indices (FICI) of antibiotic-extracts/ phases pairs, against MRSA

MRSA Staphylococcus aureus^a
Sample/Combination	Combined MIC (µg/mL)	FIC	FICI	Result
SEE + AMP			0.14	Synergism
SEE	125	0.125
AMP	25	0.0125
SHxP + AMP			0.26	Synergism
SHxP	500	0.25
AMP	25	0.0125
SEP + AMP			0.13	Synergism
SEP	62.5	0.125
AMP	12.5	0.0063
SCP + AMP			0.08	Synergism
SCP	62.5	0.0625
AMP	25	0.0125
SHP + AMP			0.08	Synergism
SHP	62.5	0.0625
AMP	25	0.0125
LEE + AMP			0.04	Synergism
LEE	31.3	0.031
AMP	25	0.0125
LHxP + AMP			0.51	Additivity
LHxP	1000	0.5
AMP	12.5	0.0063
LEP + AMP			0.51	Additivity
LEP	1000	0.5
AMP	12.5	0.0063
LCP + AMP			1	Additivity
LCP	1000	1
AMP	12.5	0.0063
LHP + AMP			0.26	Synergism
LHP	250	0.25
AMP	25	0.0125
3 + AMP			2	Indifference
3	250	1
AMP	> 2000	1
10 + AMP			2	Indifference
10	≥ 500	1
AMP	> 2000	1
18 + AMP			2	Indifference
18	≥ 500	1
AMP	> 2000	1

^aClinical strain, resistant to penicillin G and oxacillin. LEE leaves-ethanol extract, LHxP leaves-hexane phase, LEP leaves-ethyl acetate phase, LCP leaves-chloroform phase, LHP leaves-hydromethanolic phase, SEE stems-ethanol extract, SHxP stems-hexane phase, SEP stems-ethyl acetate phase, SCP stems-chloroform phase, SHP stems-hydromethanolic phase, AMP Ampicillin. For FIC calculation, MIC values of LHxP and SHxP were considered = 2000 µg/mL

ISSN: 2662-7671