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Table 2 Characteristics of multiple complex networks for topo I inhibitors from Artemisiae Scopariae Herba extract

From: Combination of bioaffinity ultrafiltration-UFLC-ESI-Q/TOF-MS/MS, in silico docking and multiple complex networks to explore antitumor mechanism of topoisomerase I inhibitors from Artemisiae Scopariae Herba

Characteristics

Symbol

Definition a

IPI b

TTI c

IPB d

PPI e

Average degree

<k>

\(<{k}>=\frac{1}{N}\sum\nolimits_{{i=1}}^{N} {{{k}_i}}\)

74.85

5

9.98

68.87

Density

  

0.79

1

0.89

0.77

Average path length

L

\(L=\frac{1}{{N(N - 1)}}\mathop \sum \limits_{{i \ne j}} {d_{ij}}\)

1.21

1

 

1.24

Diameter

D

\(D={\text{max}}\{ {d_{ij}}\}\)

2.00

1

 

3.00

Clustering coefficient

C

\({C_i}=\tfrac{{2{e_i}}}{{{k_i}({k_i} - 1)}}({k_i} \geqslant 2)\)

0.91

1

 

0.92

Degree centrality

\({C}_{d}\)

\({C_d}=\tfrac{{{k_i}}}{{N - 1}}\)

0.79

1

 

0.77

Betweenness centrality

\({C}_{b}\)

\({C_b}=\sum\limits_{{j(<{k})}}^{N} {\sum\limits_{k}^{N} {\tfrac{{{g_{jk}}(i)}}{{{g_{jk}}}}} }\)

0.01

0

 

0.03

Closeness centrality

\({C}_{c}\)

\({C_c}=\frac{{N - 1}}{{\sum\limits_{{j=1}}^{N} {{d_{ij}}} }}\)

0.84

0

 

0.83

  1. aN stands for total numbers of nodes in a network. dij stands for the shortest path length connecting node i and j. gjk stands for the quantity of geodesics from node j to k
  2. bThe ingredient-pathway interaction network
  3. cThe ingredient-ingredient interaction network
  4. dThe ingredient-pathway bimodal network
  5. eThe pathway-pathway interaction network