Fig. 7

Molecular docking analysis for the visualization of binding poses of amygdalin and sorafenib in the binding sites of (A) AKT1 (PDB ID: 6S9W); (B) HDAC1 (PDB ID: 4BKX); (C) JMJD1C (PDB ID: 2YPD); (D) LKB1 (PDB ID: 4ZDR); (E) AMPK (PDB ID: 4CFF); (F) DNMT1 (PDB ID: 4WXX); (G) PK3CA (PDB ID: 2RD0) and (H) SIRT1 (PDB ID: 5BTR). Molecular docking and interactions between ligands and receptors have been performed using InstaDock and BIOVIA discovery studio visualizer software, respectively. Amygdalin and sorafenib three-dimensional structure were downloaded from the PubChem database (https://pubchem.ncbi.nlm.nih.gov/)