Fig. 1

Effect of Sorafenib and Amygdalin on cell viability of HepG2 and WI-38 cells: Cells were treated with different concentrations of Sorafenib (0.125-8 µM) (A and C) and Amygdalin (0.5–160 mg/ml) (B and D) for 48 h and MTT assay was performed. Results were expressed as cell viability (% of control) and data are presented as the mean ± standard deviation, all experiments were repeated at least three times. (E-I) Graphic representations obtained from the CompuSyn Report (see supplementary materials 2) for Amy and Sor combinations indicating strong synergism between the two compounds when used in combo: (E) Dose-effect plot; (F) DRI plot; (G) Median-effect plot; (H) Isobolograms; and (I) Combination index blot