Fig. 7

Bioinformatics Analysis of differentially expressed proteins (DEPs). GO annotation classification analysis of the DEPs between T2DM versus normal groups (A) and MLE versus T2DM groups (B). KEGG pathway enrichment analysis of the DEPs between T2DM versus normal groups (C) and MLE versus T2DM groups (D). E Protein–protein interaction network analysis of 19 overlapping proteins in the T2DM versus normal and MLE versus T2DM groups. The proteins are represented by a circle node. The node size represents the degree of the node; the larger the node size, the higher the degree. There is a positive correlation between the thickness of the edge and the binding score value between the proteins. T2DM Type 2 diabetes mellitus, MLE Mulberry leaf extract