Fig. 6

Differentially expressed proteins (DEPs) profiles by TMT-based proteomic analysis. The volcano plots of DEPs between T2DM versus normal groups (A) and MLE versus T2DM groups (B). The X-coordinate is the logarithmic value of the relative quantitative value of the protein after the Log2 conversion, and the Y-coordinate is the P-value after the -log10 conversion. The red dots indicate significantly up-regulated proteins, and the green dots indicate significantly down-regulated proteins. The heatmap of hierarchical clustering analysis on DEPs between T2DM versus normal groups (C) and MLE versus T2DM groups (D). Red blocks represent up-regulated proteins and blue blocks represent down-regulated proteins. E Venn diagram of the distribution and overlaps of DEPs between T2DM versus normal groups and MLE versus T2DM groups. T2DM Type 2 diabetes mellitus, MLE Mulberry leaf extract