From: In vitro cytotoxic effect of stigmasterol derivatives against breast cancer cells
Compound name | MCF-12Â A | MCF-7 | HCC70 | |||
---|---|---|---|---|---|---|
EC50 and Standard deviation (µM) | R2 | EC50 and Standard deviation (µM) | R2 | EC50 and Standard deviation (µM) | R2 | |
stigmasterol (1) | NT | Â | NT | Â | NT | Â |
stigmasterol acetate (2) | NT | Â | NT | Â | NT | Â |
stigmasta-5,22-dien-3,7-dione (3) | 30.18 ± 1.24 | 0.93 | 42.85 ± 1.32 SI: 0.70 | 0.88 | 67.73 ± 1.26 SI: 0.45 | 0.91 |
5,6-epoxystigmast-22-en-3β-ol (4) | 46.97 ± 1.18 | 0.94 | 21.92 ± 1.32 SI: 2.14 | 0.82 | 165.70 ± 1.30 SI: 0.28 | 0.85 |
5,6-epoxystigmasta-3β,22,23-triol (5) | 30.18 ± 1.28 | 0.90 | 43.99 ± 1.40 SI: 0.69 | 0.84 | 33.69 ± 1.33 SI: 0.90 | 0.88 |
stigmastane-3β,5,6,22,23-pentol (6) | 22.56 ± 1.22 | 0.93 | 44.14 ± 1.40 SI: 0.51 | 0.84 | 16.82 ± 1.17 SI: 1.34 | 0.96 |
stigmasta-5-en-3,7-dion-22,23-diol (7) | 31.60 ± 1.12 | 0.93 | 23.16 ± 1.08 SI:1.36 | 0.95 | 170.10 ± 1.18 SI:0.19 | 0.80 |
stigmasta-3,7-dion-5,6,22,23-ol (8) | NT |  | NT |  | 53.23 ± 1.06 | 0.97 |
stigmast-5-ene-3β,22,23-triol (9) | 51.79 ± 1.13 | 0.92 | 22.94 ± 1.09 SI:2.26 | 0.94 | 44.54 ± 1.13 SI:1.16 | 0.91 |
DCM crude (R. tridentate) | 96.37 ± 1.19 | 0.87 | ˃250 |  | 13.82 ± 1.12 SI: 6.97 | 0.87 |
Camptothecin (nM) | 104.20 ± 1.03 | 0.99 | 103.80 ± 9.92 SI:1.00 | 0.99 | 83.17 ± 1.08 SI:1.25 | 0.99 |