Fig. 9
Histopathological examination of liver sections from rats in different groups was conducted. Group A (control) and Group B (Abs) showed light micrographs of rat liver sections. The histology of the control group exhibited normal architectures, including a central vein (star), sinusoids (red arrows), Kupffer cells (blue arrow), and hepatocytes arranged in hepatic cords (black arrows). In Group C (γ-Al2O3), the liver section displayed a central vein (CV) containing hemolysed red blood cells (blue arrow). The structure of hepatic cords and sinusoids was disrupted. Hepatocytes had dark nuclei (black arrow), and there was an increase in Kupffer cells (red arrows). Group D (Abs plus γ-Al2O3) showed a significant decrease in tissue disruption. Some areas exhibited dilated sinusoids (arrows). Accumulation of blood cells in the central vein and sinusoids was observed. In Group E (α-Al2O3), the liver section revealed a clearly congested thick-walled central vein containing hemolysed blood cells and extensive inflammatory cell infiltration (black arrow). The structure of hepatic cords was disrupted. Group F (Abs plus α-Al2O3) displayed a slightly increased number of Kupffer cells and hepatocytes (arrows) in the rat's liver section.Scale bars: 20 µm (40X)