Table 2 Eighteen differential metabolites identified from different groups

4-[5]-ladderane-butanoic acid

C16H22O2

2.750310196

1.174397407

0.04862

0.3666

2.088799602

1.10438095

0.01263

0.14

Asparaginyl-Proline

C9H15N3O4

1.335358198

1.037578288

0.0385

0.3581

1.264694445

0.96283903

0.02319

0.18

(-)-Glycinol

C15H12O5

3.049088211

1.293369664

0.00309

0.269

2.642880823

1.28674699

0.02533

0.19

Benzenemethanol, 2-(2-hydroxypropoxy)-3-methyl-

C11H16O3

1.70174831

1.076959396

0.02309

0.3376

2.238934972

1.15231119

0.00647

0.11

2-hydroxy-2-[8-hydroxy-2-methyl-2-(4-methylpent-3-en-1-yl)-2 H-chromen-5-yl]acetic acid

C18H22O5

1.590928708

0.935587762

0.03168

0.3443

1.567821886

0.92626544

0.04701

0.24

Arbutin

C12H16O7

1.927342137

0.887000596

0.003632

0.2768

2.166510528

0.85513078

7.2E-05

0.02

Naringenin-4’-O-beta-D-Glucuronide

C21H20O11

1.909917025

1.10625

0.04217

0.3617

2.112485633

1.12457454

0.00862

0.13

Phenylacetylglycine

C10H11NO3

1.505632048

0.95286253

0.03071

0.3443

1.204458293

0.96577484

0.02271

0.18

 S-(9-deoxy-delta9,12-PGD2)-glutathione

C30H47N3O10S

1.156293297

1.033232089

0.04581

0.3637

1.264550908

1.04123154

0.03162

0.2

[3-(6,7-dihydroxy-4-oxo-4 H-chromen-2-yl)phenyl]oxidanesulfonic acid

C15H10O8S

1.897366035

1.077025994

0.0144

0.3273

1.561911404

1.05980816

0.02146

0.17

(2 S)-2-amino-3-(4-hydroxyphenyl)propanoic acidL-Tyrosine

C9H11NO3

1.033002195

1.0220613

0.02957

0.3443

1.12525557

1.02812129

0.01837

0.16

Naringenin-7-O-beta-D-Glucuronide

C21H20O11

2.000183288

1.08987701

0.02153

0.3376

2.112485633

1.12457454

0.00862

0.13

Furanogermenone

C15H20O2

5.906354275

0.219909605

0.002447

0.2638

4.63574522

0.26733516

0.01212

0.14

3,5-dichlorosalicylic acid

C7H4Cl2O3

3.322460748

0.795840266

0.008505

0.3178

3.073359328

0.78979524

0.02436

0.18

Rac-5,6-Epoxy-retinoyl-beta-D-glucuronide

C26H36O9

3.122146738

1.349954393

0.04043

0.3612

2.760429353

1.33053641

0.04719

0.24

3,4,5-trihydroxy-6-[(2-pentyl-3-phenyloxiran-2-yl)methoxy]oxane-2-carboxylic acid

C20H28O8

2.20559935

1.098851518

0.002855

0.269

1.506658968

1.0609901

0.01941

0.17

Ganglioside GT3 (d18:1/20:0)

C83H146N4O37

2.007697829

1.072841134

0.005428

0.2806

1.261236796

1.03349738

0.02006

0.17

N2-Acetyl-L-ornithine

C7H14N2O3

1.286873738

0.972589329

0.004259

0.2777

1.039982589

0.9754541

0.02507

0.18