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Table 5 Anti-biofilm activity of compounds

From: Evaluation of anti-quorum sensing and antibiofilm effects of secondary metabolites from Gambeya lacourtiana (De Wild) Aubr. & Pellegr against selected pathogens

Compound

Microorganism

S. aureus

E. coli

C. albicans

MIC

MIC/2

MIC/4

MIC/8

MIC

MIC/2

MIC

MIC/2

MIC/4

Acetylerythrodiol

30.4 ± 0.6

19.9 ± 0.6

11.3 ± 0.4

-

06.9 ± 0.2

-

21.3 ± 0.5

08.6 ± 0.1

-

Amyrincapraote

39.2 ± 0.7

18.5 ± 0.8

-

-

-

-

24.1 ± 0.3

-

-

Erythrodiol 3-O-palmitate

34.2 ± 0.6

15.6 ± 0.2

-

-

-

-

29.0 ± 0.4

12.7 ± 0.1

-

Erythrodiol

36.2 ± 0.7

14.4 ± 0.4

-

-

27.1 ± 0.3

11.6 ± 0.8

-

-

-

3-O-acetylbetulin

18.4 ± 0.3

09.8 ± 0.4

-

-

16.3 ± 0.4

-

12.8 ± 0.6

-

-

Betulinic acid

37.3 ± 0.8

23.2 ± 0.6

09.4 ± 0.7

-

38.3 ± 0.9

17.4 ± 0.5

32.8 ± 0.4

14.9 ± 0.2

-

3-O-acetyllupeol

21.5 ± 0.8

06.6 ± 0.2

-

-

08.4 ± 0.3

-

21.4 ± 0.5

10.5 ± 0.2

-

Lupeol

29.6 ± 0.1

10.5 ± 0.7

  

23.7 ± 0.9

06.2 ± 0.1

16.4 ± 1.0

05.6 ± 0.2

 

Myrianthic acid

62.4 ± 1.6

41.7 ± 0.5

22.8 ± 0.4

08.3 ± 0.2

08.9 ± 0.4

-

23.4 ± 0.3

07.85 ± 0.1

-

Pomolic acid

24.3 ± 0.3

07.6 ± 0.2

-

-

11.4 ± 0.2

-

27.7 ± 0.5

08.3 ± 0.1

-

Ursolic acid

38.7 ± 0.3

11.6 ± 0.5

-

-

34.3 ± 0.9

16.3 ± 0.2

47.5 ± 0.3

26.4 ± 0.4

08.8 ± 0.5

Taraxerone

27.9 ± 0.7

10.3 ± 0.4

-

-

14.9 ± 0.5

-

20.7 ± 0.4

04.4 ± 0.1

-

22,23-Dihydrospinasterol 3-O-β-D-glucopyranoside

-

-

-

-

-

-

-

-

-

Spinasterol

-

-

-

-

-

-

10.9 ± 0.5

-

-

Spinasterol 3-O-β-D-glucopyranoside

-

-

-

-

-

-

-

-

-

Stigmasterol

-

-

-

-

-

-

12.4 ± 0.7

-

-

Lacourtianamide

65.2 ± 1.4

41.7 ± 0.5

19.8 ± 0.9

07.0 ± 0.2

18.9 ± 0.6

05.7 ± 0.3

36.4 ± 0.6

16.5 ± 0.3

09.8 ± 0.4

Lacourtianoside II

-

-

-

-

-

-

-

-

-

Epicatechin

68.1 ± 2.3

45.7 ± 1.2

28.4 ± 0.9

11.7 ± 0.3

39.4 ± 0.9

25.5 ± 0.8

14.3 ± 0.4

-

-

Methyl pheophorbide-a

46.4 ± 0.9

25.7 ± 0.9

14.6 ± 0.8

-

-

-

38.3 ± 0.6

20.0 ± 0.5

06.3 ± 0.1

  1. -: No inhibition; values are means ± SEM for three parallel measurements