Table 1 Schedule of activities for phase ib to evaluate safety and MTD in gastrointestinal tumors and acute leukemias

Time point

Week 1

Week 2

Week 6

Week 7

Enrolment

 Screening and Informed Consent

X

 Physical Examen

X

X

X

 Clinical Record

X

X

X

 HIV Test and Pregnancy test

X

Interventions

 Medication dispensing

X

X

X

 Follow-up visit

X

X

X

Safety Assessment

 Hemogram

X

X

X

 Transaminase AST

X

X

X

 Transaminase ALT

X

X

X

 Alkaline Phosphatase

X

X

X

 Total Bilirubin

X

X

X

 Triglycerides

X

X

X

 Total Cholesterol

X

X

X

 Blood Urea Nitrogen (BUN)

X

X

X

 Creatinine

X

X

X

 Urinalysis

X

X

X

 Uric Acid

X

X

X

 LDH (Lactate Dehydrogenase)

X

X

X

 Lactic Acid

X

X

X

 Ferritin

X

X

X

 Albumin

X

X

X

 Iron

X

X

X

 Electrocardiogram

X

X

X

 Echocardiogram