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Table 3 Participant characteristics of the included interventional studies investing CAIMs delivered via telemedicine (n = 56)

From: The use and effects of telemedicine on complementary, alternative, and integrative medicine practices: a scoping review

Author, Year

Article Title

Intervention Sample Size

Control Sample Size

Intervention Drop-Out

Control Drop-Out

% Female

Mean Age (SD) or Median Age (IQR) in Years

Health Related Condition/Population

Addington et al., 2018 [25]

Convenient and Live Movement (CALM) for Women Undergoing Breast Cancer Treatment: Challenges and Recommendations for Internet-Based Yoga Research

n = 6

Not applicable

n = 2

Not applicable

100%

59 (12.7)

Cancer

Berman et al., 2009 [27]

The Effectiveness of an Online Mind–Body Intervention for Older Adults with Chronic Pain

n = 52

n = 37

n = 11

n = 0

87.80%

65.8

Chronic pain

Bombardier et al., 2013 [28]

Telephone-Based Physical Activity Counseling for Major Depression in People with Multiple Sclerosis

n = 44

n = 48

n = 0

n = 0

86%

48

MDD and MS

Cavalera et al., 2019 [29]

Online Meditation Training for People with Multiple Sclerosis: A Randomized Controlled Trial

n = 54

n = 67

n = 8

n = 23

64.40%

Intervention: 42.26 (8.35), control: 43.19 (9.02)

MS

Cheung et al., 2018 [30]

Usability Testing of a Smartphone Application for Delivering Qigong Training

Pilot: n = 14, main test: n = 100

Not applicable

n = 0

Not applicable

Pilot: 71%, main test: 74%

Pilot: 32.3 (8.7), main: 36.15 (13.525)

Cantonese or Putonghua speaking adults who owned a smartphone

Davis et al., 2015 [31]

Mindfulness Training for Smokers via Web-Based Video Instruction with Phone Support: A Prospective Observational Study

n = 26

Not applicable

n = 6

Not applicable

57.70%

40.5 (13.48)

Smokers

Dimitropoulous et al., 2017 [32]

Evaluating the Feasibility of a Play-Based Telehealth Intervention Program for Children with Prader-Willi Syndrome

n = 10

Not applicable

n = 2

Not applicable

30%

Not available

Prader-Willi syndrome

Donesky et al., 2017 [33]

Evaluation of the Feasibility of a Home-Based TeleYoga Intervention in Participants with Both Chronic Obstructive Pulmonary Disease and Heart Failure

n = 7

n = 8

n = 1

n = 2

66%

Intervention: 73 (14.3), control: 70.5 (2.7)

COPD and HF

Ezenwa et al., 2016 [34]

A Randomized Controlled Pilot Study Feasibility of a Tablet-Based Guided Audio-Visual Relaxation Intervention for Reducing Stress and Pain in Adults with Sickle Cell Disease

n = 15

n = 13

n = 3

n = 1

70%

31.70 (10.2)

Sickle cell disease

Ferraris et al., 2020 [35]

Use of Remote Monitoring by E-mail for Long-Term Management of the Classic Ketogenic Diet

n = 34

Not applicable

n = 3

Not applicable

53%

7.5 (IQR 4.0–10.00)

Drug-resistant epilepsy or GLUT-1-DS

Freeman et al., 2014 [36]

A Randomized Trial Comparing Live and Telemedicine Deliveries of an Imagery-Based Behavioral Intervention for Breast Cancer Survivors: Reducing Symptoms and Barriers to Care

n = 23

n = 47

n = 4

n = 4

100%

Intervention: 55.57 (9.88), control: 55.28 (7.90)

Cancer survivors

Gardner-Nix et al., 2014 [37]

Exploring the Effectiveness of a Mindfulness-Based Chronic Pain Management Course Delivered Simultaneously to On-Site and Off-Site Patients Using Telemedicine

n = 60

n = 59

n = 0

n = 0

75%

52

Chronic pain patients

Golebowicz et al., 2015 [38]

Efficacy of a Telerehabilitation Intervention Programme Using Biofeedback Among Computer Operators

n = 12

Not applicable

n = 0

Not applicable

50%

34.25 (8.80)

Work-related musculoskeletal disorders

Guétin et al., 2016 [40]

Smartphone-based Music Listening to Reduce Pain and Anxiety Before Coronarography: A Focus on Sex Differences

n = 35

Not applicable

n = 0

Not applicable

48.50%

61.26 (11.64)

Management of pain and anxiety in coronarography patients

Hansen et al., 2015 [41]

A Feasibility Pilot Study on the Use of Complementary Therapies Delivered via Mobile Technologies on Icelandic Surgical Patients' Reports of Anxiety, Pain, and Self-efficacy in Healing

Total: n = 81, audio-relaxation: n = 25, music: n = 25, nature video, no music: n = 16, nature video with music: n = 15

n = 24

n = 0

n = 0

80% (Note: this was calculated for the purpose of this review)

Audio-relaxation: 45.2 (13.4), music: 46 (15), nature video, no music: 44.60 (16.5), nature video with music: 43.90 (13.5)

Same day surgery patients

Hasan et al., 2019 [42]

Skye Hypnotherapy for Irritable Bowel Syndrome: Effectiveness and Comparison with Face-to-Face Treatment

n = 20

Not applicable

n = 0

Not applicable

75%

38.40

Irritable bowel syndrome

Hernandez et al., 2018 [43]

Feasibility of an Internet-Based Positive Psychological Intervention for Hemodialysis Patients with Symptoms of Depression

n = 14

Not applicable

n = 2

Not applicable

50%

57.43 (12.12)

Hemodialysis patients with symptoms of depression

Horneber et al., 2018 [44]

Addressing Unmet Information Needs: Results of a Clinician-Led Consultation Service About Complementary and Alternative Medicine for Cancer Patients and Their Relatives

Total: n = 5259, patients: n = 3009, caregivers: n = 2260

Not applicable

n = 0

Not applicable

Total: 65.40%, patients: 64.10%, caregivers: 66.80%

Total: 55 (13), patients: 56 (12), caregivers: 49 (15)

Cancer patients and relatives

Houweling et al., 2015 [45]

First-Contact Care with a Medical vs Chiropractic Provider After Consultation with a Swiss Telemedicine Provider: Comparison of Outcomes, Patient Satisfaction, and Health Care Costs in Spinal, Hip, and Shoulder Pain Patients

n = 316

n = 403

n = 0

n = 0

40.80%

Intervention: 41.30 (12.93), Control: 45.70 (13.87)

Spinal, hip, and shoulder pain patients

Huberty et al., 2017 [47]

Experiences of Women Who Participated in a Beta-Test for an Online-Streamed Yoga Intervention After a Stillbirth

n = 74

Not applicable

n = 22

Not applicable

100%

33.73 (4.38)

Women after a stillbirth

Hucker et al., 2014 [48]

An Online, Mindfulness-Based, Cognitive-Behavioral Therapy for Female Sexual Difficulties: Impact on Relationship Functioning

n = 26

n = 31

n = 20

n = 6

100%

Intervention: 33.31 (7.4), control: 31.94 (5.17)

Female sexual difficulties

Kahn et al., 2016 [49]

Post-9/11 Veterans and Their Partners Improve Mental Health Outcomes With a Self-Directed Mobile and Web-Based Wellness Training Program: A Randomized Controlled Trial

n = 240

n = 80

n = 4

n = 0

Veterans: 19%, partners of veterans: 93%

Not available

Post-9/11 veterans

Kemper et al., 2017 [50]

Online Training in Mind–Body Therapies: Different Doses, Long-Term Outcomes

n = 149

Not applicable

n = 0

Not applicable

79.80%

Not available

Outcomes for health professionals

Kim et al., 2020 [51]

Telemedicine Center of Korean Medicine for Treating Patients with COVID-19: A Retrospective Analysis

n = 1742

Not applicable

n = 0

Not applicable

76.10%

Not available

Hospital patients with COVID-19

Krampe, & Musterman, 2013 [53]

Shall We Skype Dance? Connecting Nursing Students with Older Adults via Skype for Dance-Based Therapy

n = 10

Not applicable

n = 4

Not applicable

60%

Not available

Older adults in an assisted living facility

Krout et al., 2010 [54]

Designing, Piloting, and Evaluating an On-Line Collaborative Song-writing Environment and Protocol Using Skype Telecommunication Technology: Perceptions of Music Therapy Student Participants

n = 4

Not applicable

n = 0

Not applicable

75%

Not available

Song-writing students

Kubo et al., 2019 [55]

A Randomized Controlled Trial of mHealth Mindfulness Intervention for Cancer Patients and Informal Cancer Caregivers: A Feasibility Study Within an Integrated Health Care Delivery System

Patient: n = 54, caregiver: n = 17

Patient: n = 43,caregiver: n = 14

Patient: n = 14, Caregiver: n = 4

Patient: n = 11, caregiver: n = 1

66%

Patient intervention: 59.3 (14.1), caregiver intervention: 57.1 (17.4), Patient control: 56.7 (14.7), Caregiver control: 58.2 (18.6)

Cancer patients and caregivers

Lee et al., 2020 [57]

Long-term Beneficial Effects of an Online Mind–Body Training Program on Stress and Psychological Outcomes in Female Healthcare Providers: A Non-Randomized Controlled Study

n = 25

n = 31

n = 17

n = 14

100%

Intervention: 36.20 (8.17), control: 35.00 (6.74)

Female healthcare providers

Lester et al., 2019 [58]

Virtual Mind–Body Treatment for Geographically Diverse Youth with Neurofibromatosis: A Pilot Randomized Controlled Trial

n = 27

n = 24

n = 0

n = 0

41.10%

Intervention: 14.48 (1.34), control: 14.26 (1.70)

Youth with neurofibromatosis

Mussman, 2016 [59]

A Mixed-Methods Feasibility Study on the Provision of a Brief Online Yoga Intervention as e-Health for Improving Stress Management: Perceived Stress, Stage of Change for Stress management, and Self-efficacy for Stress Management and Engagement in Yoga

n = 14

Not applicable

n = 49

Not applicable

85.70%

43.86 (10.52)

Stress

Ondersma et al., 2019 [60]

Feasibility and Acceptability of e-Screening and Brief Intervention and Tailored Text Messaging for Marijuana Use in Pregnancy

n = 45

Not applicable

n = 0

Not applicable

100%

24.90 (5.2)

Cannabis users during pregnancy

Papadaki et al., 2016 [61]

Employees' Expectations of Internet-Based, Workplace Interventions Promoting the Mediterranean Diet: A Qualitative Study

n = 29

Not applicable

n = 0

Not applicable

51.70%

42.60 (9.5)

Mediterranean diet in the workplace

Petersen et al., 2017 [62]

An Online Educational Program Improves Pediatric Oncology Nurses' Knowledge, Attitudes, and Spiritual Care Competence

n = 112

Not applicable

n = 0

n = 0

98.20%

Not available

Pediatric oncology nurses

Reilly-Spong et al., 2015 [63]

Telephone-Adapted Mindfulness-Based Stress Reduction (tMBSR) for Patients Awaiting Kidney Transplantation: Trial Design, Rationale and Feasibility

n = 32

n = 31

n = 4

n = 4

57.10%

52.80 (11.7)

Patients awaiting kidney transplantation

Rickhi et al., 2015 [64]

Evaluation of a Spirituality Informed e-Mental Health Tool as an Intervention for Major Depressive Disorder in Adolescents and Young Adults—A Randomized Controlled Pilot Trial

n = 33

n = 29

n = 8

n = 4

66.67% (Note: this was calculated for the purpose of this review)

Intervention, younger age: 15.30, intervention, older age: 21, control, younger age: 15.20, control, older age: 20.90

Youth with MDD

Rogante et al., 2010 [65]

Electromyographic Audio Biofeedback for Telerehabilitation in Hospital

n = 1

Not applicable

Not applicable

Not applicable

Not available

59

A patient with arm impairment following a stroke

Rosmarin et al., 2010 [66]

A Randomized Controlled Evaluation of a Spiritually Integrated Treatment for Subclinical Anxiety in the Jewish community, Delivered via the Internet

n = 78

n = 47

n = 0

n = 0

76.60%

41.80 (13.6)

Subclinical anxiety among Jewish community

Rybarczyk et al., 1999 [67]

Comparing Mind–Body Wellness Interventions for Older Adults with Chronic Illness: Classroom Versus Home Instruction

n = 115

n = 63

n = 0

n = 0

Classroom: 80.5%, home: 83.6%, control: 81.5%

Classroom: 67.60, home: 61.50, control: 64.70

Older adults with chronic illness

Sarah et al., 2019 [68]

Effect of Telerehabilitation on Long-Term Adherence to Yoga as an Antihypertensive Lifestyle Intervention: Results of a Randomized Controlled Trial

n = 115

n = 113

n = 27

n = 26

0%

Intervention: 53.20 (6.0), Control: 53.40 (5.7)

Rehabilitation patients with hypertension

Seidler et al., 2017 [69]

Feasibility and Preliminary Efficacy of a Telerehabilitation Approach to Group Adapted Tango Instruction for People with Parkinson Disease

n = 10

n = 10

n = 3

n = 3

55%

Intervention: 68.10 (7.9), control: 68.90 (9.4)

Parkinson’s disease

Selman et al., 2015 [23]

Appropriateness and Acceptability of a Tele-Yoga Intervention for People with Heart Failure and Chronic Obstructive Pulmonary Disease: Qualitative Findings From a Controlled Pilot Study

n = 7

n = 8

n = 1

n = 2

75%

71.20 (10.09)

HF and COPD

Shrier et al., 2014 [70]

“Counselor in your pocket”: Youth and Provider Perspectives on a Mobile Motivational Intervention for Marijuana Use

n = 20

Not applicable

n = 11

Not applicable

62.50%

19.80

Youth who frequently use cannabis, and providers who treat them

Simpson et al., 2002 [71]

Video-Hypnosis—The Provision of Specialized Therapy via Videoconferencing

n = 15

Not applicable

n = 4

Not applicable

Not available

Not available

Patients with mental health problems who live in remote areas

Singh et al., 2017 [72]

Tele-Health Training of Teachers to Teach a Mindfulness-Based Procedure for Self Management of Aggressive Behavior to Students with Intellectual and Developmental Disabilities

n = 3

Not applicable

n = 0

Not applicable

0%

10.66

Students with Intellectual and Developmental Disabilities

Stubberud et al., 2020 [73]

Biofeedback Treatment App for Pediatric Migraine: Development and Usability Study

n = 10

Not applicable

n = 0

Not applicable

30%

15 (1.6)

Pediatric migraine patients

Tan et al., 2013 [74]

Improving Access to Care for Women Veterans Suffering from Chronic Pain and Depression Associated with Trauma

n = 34

Not applicable

n = 7

Not applicable

100%

49.50 (10)

Female veterans with chronic non-malignant musculoskeletal pain

Thompson et al., 2015 [75]

Expanding the Efficacy of Project UPLIFT: Distance Delivery of Mindfulness-Based Depression Prevention to People with Epilepsy

n = 62

n = 56

n = 10

n = 0

65.30%

41.20

Epilepsy

Tkatch et al., 2017 [76]

A Pilot Online Mindfulness Intervention to Decrease Caregiver Burden and Improve Psychological Well-Being

n = 40

Not applicable

n = 0

Not applicable

80%

71

Community dwelling older adult caregivers

Tucker et al., 2008 [77]

Telephone-Based Diet and Exercise Coaching and a Weight-Loss Supplement Result in Weight and Fat Loss in 120 Men and Women

n = 64

n = 64

n = 11

n = 2

50%

43 (9)

Overweight or obese adults

Uebelacker, et al., 2018 [78]

Examining the Feasibility and Acceptability of an Online Yoga Class for Mood Disorders: A MoodNetwork Study

n = 56

Not applicable

n = 12

Not applicable

93.20%

42.0 (14.62)

Adults with a mood disorder

Vederhus et al., 2020 [79]

Can a Smartphone App for Cannabis Cessation Gain a Broader User Group than Traditional Treatment Services?

n = 148

n = 102

n = 0

n = 0

37%

Intervention: 25 (9), control: 25 (8)

Cannabis use disorder patients

Vranceanu et al., 2016 [80]

Mind–Body Therapy via Videoconferencing in Patients with Neurofibromatosis

n = 32

n = 31

n = 0

n = 10

73%

Intervention: 42.86 (13.45), control: 39.90 (11.17)

Patients with neurofibromatosis

Wang et al., 2011 [24]

Biomedical Teleacupuncture Between China and Austria Using Heart Rate Variability, Part 1: Poststroke Patients

n = 29

Not applicable

n = 0

Not applicable

51.70%

64.7 (11.3)

Post-stroke patients

Wang et al., 2016 [81]

The Effects of Music Intervention on Sleep Quality in Community-Dwelling Elderly

n = 32

n = 32

n = 0

n = 0

80.90%

69.38 (5.46)

Community-dwelling elderly

Yeh et al., 2013 [82]

Auricular Acupressure Combined with an Internet-Based Intervention or Alone for Primary Dysmenorrhea: A Control Study

n = 54

n = 53

n = 4

n = 3

100%

Intervention: 16.94 (1.02), Control: 17.94 (0.84)

Adolescents with primary dysmenorrhea

Zwart et al., 2000 [84]

The Impact of Lay Pastoral Telecare on the Spiritual Well-Being of Church Attenders

n = 64

n = 63

n = 10

n = 9

71.60%

37.90 (9.84)

Spiritual well-being in church attenders

  1. Abbreviations: COPD Chronic Obstructive Pulmonary Disease, GLUT1-DS Glucose transporter type 1 deficiency syndrome, HF Heart failure, IQR Interquartile range, MDD Major Depressive Disorder, MS Multiple sclerosis, N/A Not applicable, SD Standard deviation
  2. Armin et al., 2020 [26] was excluded as the sub-groups could not be broken down. Green et al., 2020, Hu et al., 2013, [46] Kwon et al., 2020, [56] and Zini et al., 2018 [83] were excluded as they were non-interventional studies. Krampe et al., 2016 [52] was excluded as the sample described was the same as the Krampe & Musterman 2013 study [53]