Fig. 1

Effect of preparation technique on the physio-chemical properties of drug-loaded nanoparticles. (A) polymeric NPs sizes. The figure shows polymeric nanoparticles which were prepared by nanoprecipitation method (F2) were significantly lower in size compared to drug-loaded NP formulations fabricated by O/W single emulsion solvent evaporation technique (F1) (B) polydispersity index (PDI) values. The figure shows the size distribution of NPs produced by nanoprecipitation is more uniform and homogenous compared to those prepared by other techniques with significant decrease in polydispersity index (PDI) values. (C) zeta potential of both types of NPs. The figure shows zeta potential of both types of NPs exhibited non-significant change. (D) drug entrapment efficiency (%EE). The figure shows a sharp increase in %E.E of naringenin and Boswellia was observed in case of NP prepared by nanoprecipitation compared to other NPs. However, %E.E of Curcumin showed non-significant increase