Table 5 Inhibitory activities of compounds 1–9 on α-glucosidase and cholinesterase
Compound | α-Glucosidase IC50 (μM) | AChE IC50 (μM) | BChE IC50 (μM) |
|---|---|---|---|
1 | > 800 | 113.10 ± 0.04 | 58.12 ± 0.12 |
2 | > 800 | 0.08 ± 0.00 | 3.02 ± 0.12 |
3 | 1.60 ± 0.17 | 862.10 ± 5.85 | 321.69 ± 2.14 |
4 | 31.4 ± 0.18 | 425.20 ± 2.66 | 265.9 ± 1.79 |
5 | > 800 | > 1000 | > 1000 |
6 | > 800 | > 1000 | > 1000 |
7 | > 800 | > 1000 | > 1000 |
8 | > 800 | > 1000 | > 1000 |
9 | > 800 | > 1000 | > 1000 |
Acarbose | 60.87 ± 1.02 | Not tested | Not tested |
Donepezil | Not tested | 0.10 ± 0.00 | 3.58 ± 0.08 |