Skip to main content
Fig. 2 | BMC Complementary Medicine and Therapies

Fig. 2

From: Cardioprotective effects of Schisantherin A against isoproterenol-induced acute myocardial infarction through amelioration of oxidative stress and inflammation via modulation of PI3K-AKT/Nrf2/ARE and TLR4/MAPK/NF-κB pathways in rats

Fig. 2

Effect of SCA treatment on ISO-induced changes in cardiac biochemical markers in rats. (A): Creatine kinase-MB (CK-MB); (B): Cardiac Troponin I (cTnI); (C): Brain natriuretic peptide (BNP); (D) Histopathological changes through hematoxylin and eosin (H&E) staining in heart. ISO or SCA treated group shows myocardial damage with fragmented and separated cardiac muscle fibers (black arrow). Vascular leakage of RBCs is indicated by blue arrows. The ISO group also exhibits necrosis (*) and inflammatory cell infiltration. Fibrosis is shown by the green arrow. C: Control rats; MI: Isoproterenol (ISO) induced myocardial infarction (MI) in rats; 5 SCA: Treatment of ISO-induced rats with 5 mg SCA/ kg body weight; 10 SCA: Treatment of ISO-induced rats with 10 mg SCA/ kg body weight. The data is presented as mean ± SD (n = 10). Statistical analysis was performed using One-Way ANOVA followed by Tukey’s post hoc analysis to compare differences between groups. Mean values with different superscripts indicate significant differences at a significance level of p < 0.05. Scale bar = 50 μm. Magnification: X400

Back to article page

BMC Complementary Medicine and Therapies

ISSN: 2662-7671

Contact us