From: Shenkang protects renal function in diabetic rats by preserving nephrin expression
Control | Diabetic Nephropathy | Shenkang | Valsartan | Group difference | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | Mean | SD | N | Mean | SD | N | Mean | SD | N | Mean | SD | Pvalue | Pairwise difference | |||||
Body Measure | ||||||||||||||||||
KW/BW (%) | 15 | 0.41 | 0.12 | 15 | 0.67 | 0.12 | 15 | 0.52 | 0.08 | 15 | 0.54 | 0.14 | < 0.01 | NC-DN, NC-V, DN-SK, DN-V | ||||
Urine measures | ||||||||||||||||||
Urinary protein (mg/L) | 15 | 647.67 | 375.52 | 15 | 852.27 | 585.58 | 15 | 710.6 | 392.24 | 15 | 1103 | 582.72 | 0.08 | |||||
Urinary albumin (mg/L) | 15 | 15.03 | 4.77 | 15 | 24.78 | 9.83 | 15 | 19.13 | 6.67 | 15 | 15.03 | 6.03 | < 0.01 | NC-DN, DN-V | ||||
Urine urea nitrogen (mmol/L) | 15 | 436.27 | 212.65 | 15 | 457.17 | 212.4 | 15 | 435.4 | 213.89 | 15 | 389.5 | 108.89 | 0.96 | |||||
Urine creatinine (µmol/L) | 15 | 4327.4 | 1915.04 | 15 | 3367.3 | 1290.13 | 15 | 3765.2 | 1057.02 | 15 | 2747.35 | 887.8 | 0.02 | NC-V | ||||
ACR (ug/mg) | 15 | 33.48 | 11.86 | 15 | 68.51 | 26.28 | 15 | 45.62 | 12.47 | 15 | 50.18 | 15.69 | < 0.01 | NC-DN, NC-V, DN-SK, DN-V | ||||
Blood measures | ||||||||||||||||||
CHO (mmol/L) | 15 | 1.62 | 0.42 | 15 | 1.87 | 0.42 | 15 | 1.83 | 0.39 | 15 | 1.53 | 0.23 | 0.02 | DN-V | ||||
TG (mmol/L) | 15 | 0.58 | 0.22 | 15 | 0.82 | 0.34 | 15 | 0.99 | 0.25 | 15 | 0.9 | 0.61 | < 0.01 | NC-SK | ||||
LDL (mmol/L) | 15 | 0.41 | 0.1 | 15 | 0.54 | 0.17 | 15 | 0.57 | 0.16 | 15 | 0.45 | 0.13 | 0.01 | NC-SK | ||||
BUN (mmol/L) | 15 | 10.19 | 3.4 | 15 | 18.47 | 6.13 | 15 | 14.11 | 4.45 | 15 | 18.53 | 6.84 | < 0.01 | NC-DN, NC-SK, NC-V | ||||
Serum creatinine (µmol/L) | 15 | 135.4 | 11.79 | 15 | 143.67 | 24.84 | 15 | 111.87 | 11.51 | 15 | 137.47 | 17.49 | < 0.01 | NC-SK, DN-SK, V-SK |