Table 6 Comparative anticancer effects of Annona muricata L fruits and leaves on different parameters in DMBA-induced breast cancer in rats
Annona muricata L (200 mg/kg BW daily) | ||||
|---|---|---|---|---|
N° | Parameters | NC | Leaves | Fruits |
1 | Flavonoid (µg ES/g DW) | - | 27.95 ± 6.35 | 21.95 ± 1.76 |
2 | Tannin (mg EAT/g DW) | - | 6.32 ± 1.5 | 12.07 ± 2.1 |
3 | Antioxidant FRAP | - | 3.46 ± 0.25 | 2.97 ± 0.25 |
4 | Antioxidant DPPH | - | 40.44 ± 2.25 | 32.60 ± 1.77 |
5 | Rate of death | 62.5% | 75% | 87.53% |
6 | Incidence of tumors | 100% | 25% | 37.5% |
7 | Tumor weight (mg/kg) | 13.4 ± 1.8 | 6.9 ± 1.4 | 1.3 ± 0.6 |
8 | % inhibition tumor burden | - | 73.5% | 89.60% |
9 | Tumor volume (cm3) | 7.2 ± 0.8 | 0.52 ± 0.01 | 0.43 ± 0.02 |
10 | CA15-3 level (U/ml) | 4.18 ± 0.93 | 0.62 ± 0.15 | 2.7 ± 0.07 |
11 | Histopathology tumors | SBR III | SBR II + 30% TIL | SBR II + 20% TIL |
12 | TNF-α (pg/mL) | 527.61 ± 13.09 | 348.6 ± 24.48 | 341.4 ± 20.61 |
13 | IFN γ (pg/mL) | 310.21 ± 31.94 | 641.66 ± 21.61 | 674.66 ± 29.69 |
14 | EGF (pg/mL) | 262.2 ± 23.64 | 110.6 ± 19.06 | 77.74 ± 11.71 |
15 | IL-6 (pg/mL) | 567.59 ± 6.99 | 521.40 ± 7.15 | 519.96 ± 4.88 |
16 | IL-12 (pg/mL) | 477.06 ± 7.89 | 446.80 ± 7.16 | 453.53 ± 8.25 |
17 | Proteins in tumor (g/l) | 0.9 ± 0.01 | 0.1 ± 0.02 | 0.1 ± 0.00 |
18 | CAT (mM of H2O2/min/mg P) | 4.6 ± 0.25 | 8.3 ± 1.5 | 9.8 ± 0.36 |
19 | MDA(mM/mg P) | 40.2 ± 1.04 | 39.3 ± 4.2 | 14.5 ± 6.8 |
20 | GSH (mM/mg P) | 11.3 ± 1.6 | 22.1 ± 1.5 | 26.4 ± 1.2 |
21 | SOD (unity/mg P) | 0.61 ± 0.3 | 1.3 ± 0.2 | 1.3 ± 0.3 |
22 | ALAT (U/I) | 362.3 ± 11.6 | 259 ± 25.8 | 113.2 ± 22.4 |
23 | Créatinine (g/l) | 0.75 ± 0.2 | 0.43 ± 0.06 | 0.32 ± 0.02 |
24 | WBC (×103/µl) | 15.42 ± 0.51 | 9.9 ± 1 | 6 ± 1.1 |
25 | RBC (×103/µl) | 5.58 ± 0.76 | 6.6 ± 0.4 | 7.1 ± 0.4 |
26 | Prevent the DMBA-induced damage | ++ | ++ | |