Comparative anticancer effects of Annona muricata Linn (Annonaceae) leaves and fruits on DMBA-induced breast cancer in female rats

Table 4 Effect of A. muricata on some parameters of oxidative stress, alanine transaminase (ALT) activity and creatinine level

	NOR	DMBA	TAMOX	AML	AMF_3 days	AMF_daily
Proteins (g/l)	0.3 ± 0.01	0.9 ± 0.01#	0.7 ± 0.02	0.1 ± 0.02**	0.6 ± 0.01	0.1 ± 0.003**
Catalase(mM of H₂O₂/min/mg P)	2.36 ± 0.4	4.6 ± 0.25	3.7 ± 0.7	8.3 ± 1.5	8.7 ± 0.62*	9.8 ± 0.36**
MDA(mM/mg P)	9.3 ± 0.9	40.2 ± 1.04##	15.1 ± 1.02*	39.3 ± 4.2	25.75 ± 5.03	14.5 ± 6.8*
GSH(mM/mg P)	25.3 ± 2.8	11.3 ± 1.6##	25.8 ± 2.4 **	22.1 ± 1.5*	17.1 ± 2.2	26.4 ± 1.2**
SOD(unity/mg P)	1.3 ± 0.2	0.61 ± 0.3	1.71 ± 0.2*	1.3 ± 0.2*	1.0 ± 0.01	1.3 ± 0.3*
ALAT(U/I)	230.6 ± 35.6	362.3 ± 11.6##	259 ± 36.9*	259 ± 25.8*	35.6 ± 9.9***	113.2 ± 22.4**
Créatinine(g/l)	0.33 ± 0.1	0.75 ± 0.2#	0.4 ± 0.1	0.43 ± 0.06	0.38 ± 0.02	0.32 ± 0.02*

Normal (NOR) and negative control (DMBA) groups received distilled water (vehicle); Tamox + DMBA = rats serving as positive control, treated with tamoxifen at 3.3 mg/kg BW; AML + DMBA = rats treated with the ethanolic extract of A. muricata leaves at 200 mg/kg BW. AMF = rats treated with A. muricata pulp fruit aqueous extract at 200 mg/kg BW at 2 different frequencies (3 times/week and every day). Significance compared to the NOR group: #p < 0.05, ##p < 0.01. Significance compared to the DMBA group: *p < 0.05, **p < 0.01, ***p < 0.001. mg P = mg of proteins

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