Comparative anticancer effects of Annona muricata Linn (Annonaceae) leaves and fruits on DMBA-induced breast cancer in female rats

Table 2 Chemo-preventive activity of A. muricata L. leaves and fruit extracts after 20 weeks of treatment

	Nber of rats with tumor	Tumor incidence (%)	Tumor weight (mg/kg)	Tumor burden (g)	Inhibition in tumor burden (%)
NOR	0/8	0%	-	-	-
DMBA	8/8	100%	13.4 ± 1.8	972.9	-
Tamox	1/8	12.5%	3.07 ± 0.02***	295.2	69.7
AML	2/8	25%	6.9 ± 1.4***	257.7	73.5
AMF_3 days	5/8	62.5%	2.2 ± 0.04***	397.9	59.1
AMF_Daily	3/8	37.5%	1.3 ± 0.6***	100.8	89.6

Normal (NOR) and negative control (DMBA) groups received distilled water (vehicle); Tamox + DMBA = rats serving as positive control, treated with tamoxifen at 3.3 mg/kg BW; AML + DMBA = rats treated with the ethanolic extract of A. muricata leaves at 200 mg/kg BW; AMF = rats treated with A. muricata pulp fruit aqueous extract at 200 mg/kg BW at 2 different frequencies (3 times/week and daily). Significance compared to the DMBA group: ^***p < 0.001 (n = 8)

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