| Baseline | Intervention | Follow-up | ||
---|---|---|---|---|---|
Week − 1 | Week 0 | Week 6 | Week 12 | Week 18 | |
Patients | Â | Â | Â | Â | Â |
 Enrollment | x |  |  |  |  |
 Signed informed consent | x |  |  |  |  |
 Randomization and allocation | x |  |  |  |  |
 Intervention |  | x | x | x |  |
Outcomes | Â | Â | Â | Â | Â |
 WOMAC-pain | x |  | x | x | x |
 WOMAC-stiffness | x |  | x | x | x |
 WOAMC-phsical function | x |  | x | x | x |
 Isokinetic dynamometry | x |  |  | x |  |
 Gait analysis with EMG | x |  |  | x |  |
 SF-36 | x |  | x | x | x |
 Dose of pain-reliving medicine | x | x | x | x | x |
Adverse events | Â | x | x | x | x |