Gallic acid and metformin co-administration reduce oxidative stress, apoptosis and inflammation via Fas/caspase-3 and NF-κB signaling pathways in thioacetamide-induced acute hepatic encephalopathy in rats

Table 3 Ludwig system for grading hepatic inflammation and fibrosis [27]

Lobular inflammation and necrosis	Portal inflammation and necrosis	fibrosis	Activity description	Score
None	None	None	No activity	0
spotty	Patchy	Portal fibrosis	Minimal	1
little hepatocellular damage	little portal tract damage	Periportal fibrosis	mild	2
noticeable hepatocellular change	noticeable change in all portal tract	Septal fibrosis	Moderate	3
diffuse hepatocellular damage	Bridging necrosis	Cirrhosis	Sever	4

ISSN: 2662-7671